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Awareness Design by Cher

 

Research Projects

 

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Autism Research Centre (ARC)

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The Autism Genetic Resource Exchange (AGRE)

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The Autism Research Unit at the University of Sunderland

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Autism Research at the National Institute of Mental Health (NIMH)

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Autism Research Centre - Professor Simon Baron-Cohen   Director

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Autism Research Disorders - From Genotyping to Prospective Identification and Prevention.

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Canadian Autism Intervention Research Network

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Clinical Trials Index

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Cure Autism Now - Clinical Studies Seeking Participation

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Laboratory for Research into Autism / University of Cambridge (UK)

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National Alliance for Autism Research  - Grants & Research

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National Autism Association - Proposal for Autism & GI Pilot Studies; Vaccine Safety Datalink Study

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Northwest Autism Foundation & Harvard University and Massachusetts General Hospital

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The Autism Tissue Program - The Gift of Life  CURRENT (2000-2003) ATP BRAIN RESEARCH PROJECTS

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The Bhare Foundation - Brenen Hornstein Autism Research & Education

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The OARacle.  The Monthly E-Newsletter of the Organization for Autism Research

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The Southwest Autism Research and Resource Center (SARRC)

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Up to date Current Research listed at Online Asperger Syndrome Information and Support  (O.A.S.I.S.)

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Yale Child Center.  Developmental Disabilities Clinic - Current Research Projects
 

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What's New in the Research Field?

The 1st International Symposium on Autism Spectrum Disorder in a Forensic Context
2nd and 3rd of September 2005, Copenhagen, Denmark

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Abstract for paper presentations

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Abstract for poster presentations

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Scientific committee
 

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ABA4Autism.com and the Psychology department at the University of Tennessee at Martin are conducting a second survey on the causes of Autism Spectrum Disorders (ASD). This survey is for mothers of children with ASD as well as mothers of normally developing children who are ten years of age or younger.  Mothers who participate in the survey will receive a free ABA program to teach their children to follow directions as well as free ABA mini programs for common problems like sharing. To take the surveys please go to http://www.aba4autism.com

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'Singing' mice surprise, aid scientists - Songbirds may be the Sinatras of the animal world, but male mice can carry a tune too, say Washington University researchers who were surprised by what they heard. Scientists have known for decades that male lab mice produce high-frequency sounds - undetectable by human ears - when they pick up the scent of a female mouse. But it turns out those sounds are more complex and interesting than previously thought. By the AP

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Laughter research a first - A UNIVERSITY of Ballarat Doctor of Psychology student is conducting a research project hailed as an Australian first. Errin Jones, 24, is focussing on the social behaviour of humour and laughter in children with autism and Asperger's Disorder. She is searching for 60 participants and welcomes typically developing children and children with Downs Syndrome for comparison. She hopes her study will improve knowledge and understanding of the subject and be used as a building block for further research. "One of the major deficits with children with autism and Asperger's is that they have trouble interacting with people," Ms Jones said.

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Fish oil helps hyperactive kids - Parents across the country have been fascinated by an intriguing experiment on the BBC's Child Of Our Time documentary. Professor Robert Winston has been giving daily doses of fish oil supplements containing Omega 3 fatty acids to two children, each with different behavioural problems. Three months later, the changes have been significant. One boy's aggressive behaviour almost vanished and the other, once withdrawn and uncommunicative, has become popular and outgoing. / UK

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Computing How a Brain “Sees” / “How is it that the visual system can recognize certain objects, such as a friend in the crowd, or words on a page, despite the changing environment in which these objects are seen?. Despite the apparent ease in which we see, visual recognition is a very difficult computational problem.” - For his efforts to establish a quantitative framework aimed at describing the complex workings of the human brain, Georgetown University Medical Center neuroscientist Maximilian Riesenhuber, Ph.D., has received a five-year CAREER award from the National Science Foundation (NSF). The award, one of five given this year by the Behavioral and Cognitive Science Divison of NSF, and the only one in the Cognitive Neuroscience Initiative, is for $742,000. The prestigious NSF CAREER awards are designed to help innovative scientists, early in their profession, develop promising research programs.

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Neurofeedback Therapy Shows Promising Results in the Treatment of of ADHD and Other High Incidence Medical Disorders - Neurofeedback Therapy Shows Promising Results in the Treatment of ADHD and Other High Incidence Medical Disorders - Southwest Naturopathic Medical Center has introduced a Neurofeedback Therapy Program as part of a cutting-edge, integrative medical approach for the treatment of ADHD, and other common brain/mood disorders, including depression, autism, addiction, head injury, migraine, epilepsy and insomnia. - Southwest Naturopathic Medical Center has introduced a Neurofeedback Therapy Program as part of a cutting-edge, integrative medical approach for the treatment of attention deficit hyperactivity disorder (ADHD), and other common brain/mood disorders, including depression, autism, addiction, head injury, migraine, epilepsy and insomnia. / Release

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French psychiatrists don’t take Freud criticism lying down - A war of words has erupted among French psychiatrists after the publication of a “black book” that lambasts the teaching of Sigmund Freud and blames his followers for setting back mental health care in France by decades. In a country that is one of the last redoubts of pure Freudian psychoanalysis, the book has been like shock treatment for many in the white-coat establishment who accuse the authors of grovelling to the “Anglo-Saxon” trend towards behaviour-based mental therapy. The news magazine Le Nouvel Observateur, which published extracts of the 800-page work last month, was bombarded with letters charging it with “fascist rhetoric” and leading a “communist-style” propaganda campaign.

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Two new treatments to undergo chinical trials - Clinical trials on two new autism treatments will be undertaken in Arizona. A clinical trial is already underway testing the effects of potent vitamin and mineral supplements on children with autism. A second trial will soon begin to measure the effectiveness of a treatment designed to remove heavy metals like mercury from children's bodies. Mercury is suspected of being a potential cause for autism, which causes social withdrawal and inability to interact with others. The studies are being done under the supervision of Arizona State University chemistry professor Jim Adams and pediatrician Dr. Sanford Newmark of Tucson.

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US Medical Research Spending Rises, Results Lag - Annual U.S. spending on medical research doubled in the past decade to more than $94 billion in 2003, but the additional dollars have yielded only disappointing results, a study said on Tuesday. "There aren't a lot of diseases where we can point to and say we have an answer today that we didn't have a decade ago," said Dr. Hamilton Moses of The Alerion Institute, a North Garden, Virginia, think tank that evaluates research policy. Doctors were frustrated at not having cures to offer patients suffering from Alzheimer's disease or childhood diseases, such as autism and juvenile diabetes, he said. - Reuters

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American Academy of Pediatrics (AAP) Devotes Little Time to Autism Epidemic at October Convention Says National Autism Association - Why is the national convention of one of the most important medical organizations for children giving minimal focus to the largest developmental disorder in America? - If you look at the AAP's schedule for their national convention in Washington DC, you have to look hard for any time set aside for the biomedical aspects of Autism Spectrum Disorders. Autism now affects 1 in 166 children, making it a national epidemic that is growing beyond financial control. In fact, this unexpected rise has created problems throughout the country, making it impossible for every child with autism to get the services they need. / Release

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Study looks at new treatments - Hamilton Moses, M.D. said, "Many of the diseases for which we really need better ways of curing or preventing or treating, we have no answers. Areas like Alzheimer's disease or in the very young, autism, juvenile diabetes." That's why Dr. Moses, of the Alerion Institute, a Virginia think tank, and colleagues studied all the U.S. funding for biomedical research between 1994 and 2003. Their findings appear in a theme issue of JAMA, the Journal of the American Medical Association. The issue is called, "Medical Research -- The State of the Science." They found that the amount of research dollars increased from about $37 billion to $94 billion. After adjusting for inflation, that increase is double the money. By Julie Chapman

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Imaginative play doesn't compromise masculinity - Q. My husband is concerned that our 8-year-old son prefers imaginative play over playing games such as catch or shooting hoops. He is an excellent student and is reasonably well-behaved. While his friends at school are boys, at home he plays with two neighbor girls, ages 8 and 10. Together, they pretend they are acting in "Star Wars" movies or are detectives trying to solve a mystery - that sort of thing. Also, should I be concerned of hand-flapping when he gets excited about something or sees someone he is happy to see? Those are, by the way, the only times I've seen the hand-flapping. Thank you for any comments...

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ocial communication disorders and the brain - Through the sea of helmets and jerseys, the quarterback spots his receiver downfield and lets loose with a pass. The receiver didn't run where he was supposed to, but the quarterback's pass landed right in his hands for a touchdown. How does the quarterback know where the receiver is going to be when he throws the ball? A percussionist in the back row of a symphony orchestra watches her conductor through a forest of bows, bobbing heads, and instruments. She can see the baton and only the conductor's arm, how does she recognize her cue to come in? At a party, a man sees a woman across a crowded room, and decides that she is also interested in getting to know him better. What social signals does he pick up that will make him go over to her and begin a conversation?

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Liars' brains really are made of different stuff - Fibbing ability linked to the leetle white cells - Pathological liars' brains are different from normal people's. The fibbers had up to 26 per cent more white matter than the honest folk, a study has found, suggesting that it is the white matter that allows people to deceive, and that pathological liars may not always be in complete control of their porkies. The findings, published in the British Journal of Psychiatry, are in line with similar research into autism. Autistic people have more grey matter than non-autistic people, and generally find it much harder to lie. By Lucy Sherriff

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6 States Chosen for Youth and Environment Study - Pregnant women and others of childbearing age in six states will be the first participants in the largest-ever U.S. study of children that will track 100,000 kids from the womb to age 21 to learn how the environment affects their health, the Associated Press reported. Participating communities and the institutions leading the research will include:

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Orange County, Calif.; University of California, Irvine.

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Duplin County, N.C.,; University of North Carolina at Chapel Hill.

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Queens County, N.Y.; Mount Sinai School of Medicine.

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Montgomery County, Pa.; Children's Hospital of Philadelphia and Drexel University.

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Salt Lake County, Utah; University of Utah.

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Waukesha County, Wis.; University of Wisconsin-Madison and Medical College of Wisconsin.

The researchers plan to enroll 1,500 women in each county over five years. They will record environmental exposures during pregnancy and assess how each one may have contributed to the subsequent onset of pediatric diseases, including asthma, learning disabilities, and autism, the AP reported.

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100,000 US children will be tracked from birth through adulthood - "We're looking to find the root causes of many common diseases and disorders. When we do, we'll be in a position to prevent them from ever occurring," said U.S. Surgeon-General Dr. Richard Carmona. Researchers hoping to determine the causes of many common diseases like autism and diabetes will follow 100,000 U.S. children from birth through adulthood in the largest ever study of its kind.  "We're looking to find the root causes of many common diseases and disorders. When we do, we'll be in a position to prevent them from ever occurring," said U.S. Surgeon-General Dr. Richard Carmona. In particular, scientists will try to find out whether there is a link between environment and diseases.  Most studies used now to link environment and disease are retrospective, meaning they rely on a patient's or a parent's recall of events, food eaten, and behaviours. Scientists place much greater faith in studies that look at actual behaviours in real time to more accurately link them to consequences.

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Regional round table on autism held in Casablanca / The Association Casablancaise des Pédiatres Privés (ACPP) has organized recently in Casablanca a round table on autism, in collaboration with the Secretary of State in charge of family, childhood and disabled persons, Yasmina Baddou. - The meeting, presided by Baddou, gave the participants the opportunity to debate on the definition of autism, its diagnosis and symptoms and the role of paediatricians in the treatment of the disease. The round table was held within the framework of “2005 activities: the year of autism in Morocco”. It aimed at discussing the relation between autism and other neurological diseases and, and determine and educational approach to the results of the national colloquium on the premature diagnosis of autism. By the Morocco TIMES

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MIT Launches Major Autism Initiative - With the help of a $7.5 million grant from the New York-based Simons Foundation founded by James and Marilyn Simons, MIT brain researchers are undertaking an ambitious multi-faceted approach to understanding the genetic, molecular and behavioral aspects of autism. Autism, which affects as many as 1.5 million people, is considered the fastest growing developmental disability in America. Typically appearing during the first three years of life, autism is characterized by impairment in social interaction and communication abilities and by repetitive behaviors. Services for autistic adults cost $90 billion a year. Early diagnosis and intervention can cut the cost of lifelong care by two-thirds. By MIT

 

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enetic involvement in psychiatric diseases -Two New Jersey research teams are reporting discoveries about the biological nature of psychiatric disorders that may bring them closer to the ultimate goal of finding cures for complex diseases, such as autism and schizophrenia. Scientists at Rutgers, The State University of New Jersey, in collaboration with colleagues at the University of Medicine and Dentistry of New Jersey (UMDNJ) have unveiled new information regarding the genetic, cellular and neurological bases of susceptibility to these diseases.

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Autism Research Study in Phoenix and Tucson Areas - Researchers at Southwest College of Naturopathic Medicine (SCNM) are investigating heavy metal toxicity and autism in an upcoming chelation study called "DMSA Treatment of Children with Autism and Heavy Metal Toxicity."-  With autism spectrum disorders affecting about 1 in 166 children in the United States, researchers are scurrying to discover causes and treatments. The effects of heavy metals on autism are currently unknown. Researchers at Southwest College of Naturopathic Medicine (SCNM) are investigating heavy metal toxicity and autism in an upcoming chelation study. The study, "DMSA Treatment of Children with Autism and Heavy Metal Toxicity" will be led by Matthew Baral, N.D., Assistant Professor of Pediatric Medicine at SCNM. The team of researchers, including James B. Adams, Ph.D., Adjunct Professor in the Division of Basic Medical Sciences at SCNM, Walter Crinnion, N.D., Director of the Environmental Medicine Center of Excellence at SCNM, and Sanford Newmark, M.D., from the Center for Pediatric Integrative Medicine in Tucson, AZ will begin enrolling participants in this two-part research study in October 2005.

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PUBLIC URGED TO HELP SHAPE RESEARCH - The Medical Research Council (MRC) and the National Autistic Society (NAS), today invited people with autism, along with parents, carers and researchers to a pioneering forum to help shape MRC-funded research into the condition. Both organisations have joined forces to host the event, set to take place on September 8 at Hamilton House, Mabledon Place, central London from 10am to 3.30pm. Participants will hear about new research funded by the Department of Health and the MRC and be given a chance to discuss the latest medical developments with researchers.Top medical professionals in the field of autism will be present at the event and are looking forward to hearing the views of people living with the condition. By Dan Webber

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Autism linked to parents with high level of education / Parents of autistic children tend to be more highly qualified than parents of children with other mental problems, according to a controversial study for the Department of Health. - Parents of autistic children tend to be more highly qualified than parents of children with other mental problems, according to a controversial study for the Department of Health. It also links a wide range of "clinically recognisable" mental health problems in youngsters to divorce and family breakdown. The study of 7,977 children found that one in 10 children between the ages of five and 16 had a mental disorder. But unlike children with more common disorders, autistic children had better educated parents: 46 per cent had parents with qualifications above GCSE compared with 35 per cent of other children. / Europe

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Autism Behaviour Types Are Not Genetically Linked / Scientists at the MRC (Medical Research Council, UK) Social, Genetic and Developmental Psychiatry Centre at the Institute of Psychiatry, King's College London, have discovered that two sets of behaviours that co-occur in autism spectrum conditions appear to be caused by different sets of genes.  - The report by Dr Angelica Ronald in collaboration with Professor Robert Plomin and Dr Francesca Happé - published in Developmental Science - could help advance future diagnosis, treatment and understanding of autism spectrum conditions. / Release

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Changes in the brain may explain teenage troubles - Teenage angst and clashes with authority may be caused by changes in youngsters' brains during puberty, but luckily for harassed parents the problems pass. The ability of boys and girls to decode social cues and recognize emotions, particularly anger and sadness, dips between the ages of 12 and 14, researchers at University College London and the Institute of Child Health have discovered." It would appear that this is a function of the development of their brain at that time," Professor David Skuse, of the group's behavioral science unit, told a conference on Thursday.  By Patricia Reaney

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Science throws new light on why teenage Kevin finds life so unfair - Neuroscientists have solved the great Kevin conundrum. The comedian Harry Enfield's creation, the petulant teenager Kevin, finds life unfair because he cannot recognise paternal wrath, maternal sadness or even a tut-tutting tone of voice. Researchers have found that teenage angst and clashes with authority may be caused by changes in the brain during puberty, but luckily for harassed parents the problems pass. The ability of boys and girls to decode social cues and recognise emotions, particularly anger and sadness, dips between 12 and 14, according to a study by University College London and the Institute of Child Health.  By Tim Radford, science editor

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Blame those tantrums on brain - TEENAGE ANGST and clashes with authority may be caused by changes in youngsters' brains during puberty, but luckily for harassed parents the problems pass. The ability of boys and girls to decode social cues and recognise emotions, particularly anger and sadness, dips between ages 12 and 14, researchers at University College London and the Institute of Child Health have discovered. "It would appear that this is a function of the development of their brain at that time," Prof David Skuse, of the group's behavioural science unit, said on Thursday. By Reuters

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Rare eye-movement disorder may shed light on brain and and cardiovascular development / Unexpected findings may lead to new research directions in developmental biology - Researchers at Children's Hospital Boston, who specialize in studying the genetics of rare eye-movement disorders, have found a rare genetic syndrome whose implications go far beyond the eye, raising intriguing questions about human cardiovascular and brain development. The syndrome involves a mutation to HOXA1, a gene that has been extensively studied in mice, but about which little is known in humans. HOXA1 belongs to a large family of HOX genes that govern very early embryonic development and the making of the body plan. HOXA1 is the first HOX gene turned on in mice, and presumably in the human body, and is involved in patterning of the growth of the head, face, and brainstem. / Release

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One way to unravel the riddle of autism - Two big scientific debates have attracted a lot of attention over the past year. One concerns the causes of autism, while the other addresses differences in scientific aptitude between the sexes. At the risk of adding fuel to both fires, I submit that these two lines of inquiry have a great deal in common. By studying the differences between male and female brains, we can generate significant insights into the mystery of autism. By Simon Baron-Cohen

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Collaborations yield new discoveries in psychiatric genetics / Two New Jersey research teams are reporting discoveries about the biological nature of psychiatric disorders that may bring them closer to the ultimate goal of finding cures for complex diseases, such as autism and schizophrenia. - Scientists at Rutgers, The State University of New Jersey, in collaboration with colleagues at the University of Medicine and Dentistry of New Jersey (UMDNJ) have unveiled new information regarding the genetic, cellular and neurological bases of susceptibility to these diseases. Using data drawn from the Rutgers Cell and DNA Repository on 518 families, each with multiple autistic children, James Millonig and Linda Brzustowicz, assisted by Emanuel DiCicco-Bloom, led a team that further substantiates the link between autism and Engrailed 2 (EN2), a gene important in central nervous system development. Their research is presented in the November issue of the American Journal of Human Genetics (AJHG). / Release

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Autism expert starts MIND speaker series - The UC Davis M.I.N.D. Institute will host Rebecca Landa, professor of psychiatry at the Johns Hopkins School of Medicine, on Wednesday starting at 4 p.m. The program will be held at the UCD M.I.N.D. Institute, 2825 50th St., Sacramento, Landa is the first speaker in its fourth annual Distinguished Lecturer Series. Landa is internationally recognized for her research on neuropsychological and communication processes in autism across the lifespan. She will present two lectures. During her technical presentation at 4 p.m., Landa will review results from a longitudinal study of the social, cognitive, motor and communicative development of infants at high risk for developing autism and their implications for identifying early signs of autism spectrum disorders.

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Eccentricity can cross the line - Ask anybody what adjective goes best with the word "professor," and the answer will almost certainly be "absentminded," or possibly "nutty."  Popular culture is full of addlebrained academics, whether they be villainous madmen like Professor Morbius in Forbidden Planet or Sherlock Holmes's archenemy Professor Moriarty; crazy cranks like Professor Emmett Brown in Black to the Future, or well-meaning but harebrained eccentrics like Professor Brainard in The Absent-Minded Professor, Professor Branestawm in Norman Hunter's children's television series, Professor Pat Pending in the Hanna Barbera cartoon Wacky Races, or Professor Dumbledore of Harry Potter fame. By Mikita Brottman

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Pathological liers found to have less gray matter - According to the latest research pathological liars may have structural abnormalities in their brains. In a new study Dr. Adrian Raine and Yaling Yang of the University of Southern California, and colleagues found that individuals who habitually lied and cheated had less gray matter and more white matter in their prefrontal cortex than normal people. In the past studies have found that the prefrontal cortex shows heightened activity when normal people lie, and it is believed to be involved in both learning moral behavior and feeling remorse. According to Raine, because gray matter consists of brain cells, while white matter forms the "wiring" or connections between these cells, pathological liars may have more capacity to lie and fewer moral restraints.

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Newly discovered role of MECP2 gene in Rett Syndrome / Huda Zoghbi, of Baylor College of Medicine and the Howard Hughes Medical Institute and Juan Young, also of Baylor and colleagues report in the online Early Edition of the Proceedings of the National Academy of Science, posted the week of October 17, 2005, that the Rett Syndrome gene, MECP2, regulates RNA splicing. This work was funded in part by the Rett Syndrome Research Foundation (RSRF). - Rett Syndrome (RTT) is a severe neurological disorder diagnosed almost exclusively in girls. Children with RTT appear to develop normally until 6 to 18 months of age, when they enter a period of regression, losing speech and motor skills. Most develop repetitive hand movements, irregular breathing patterns, seizures and extreme motor control problems. RTT leaves its victims profoundly disabled, requiring maximum assistance with every aspect of daily living. There is no cure.

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NIH joined by advocacy groups to fund research on autism ... - Five institutes at the National Institutes of Health (NIH) and three private autism organizations have formed a consortium to pursue their common goal of understanding a devastating disorder. This public-private partnership has funded five grants representing three projects to identify genes that may contribute to the development of autism and Autism Spectrum Disorders. The National Institute of Mental Health will administer the $10.8 million awards over the next five years. The participating NIH institutes are The National Institute of Child Health and Human Development (NICHD), The National Institute on Deafness and Other Communication Disorders (NIDCD), The National Institute of Environmental Health Sciences (NIEHS), The National Institute of Mental Health (NIMH), and The National Institute of Neurological Disorders and Stroke (NINDS). The voluntary organizations contributing funds are Cure Autism Now (CAN), National Alliance for Autism Research (NAAR), and the Southwest Autism Research & Resource Center (SARRC).

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Gene discovery may help elderly blindness - University of Pittsburgh researchers have found a gene linked to age-related maculopathy, the leading cause of untreatable blindness in elderly people. The researchers said the discovery suggests a simple test might be able to identify those at risk for what is commonly known as macular degeneration and may lead to more effective preventive strategies.

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Letter: Climbing mountains for autism research / To the Editor -   One in 166 kids born in the U.S. will be diagnosed with autism. Autism encompasses a group of disorders characterized by deficits in social interaction and communication and unusual and repetitive behavior. The degree of autism varies from mild to severe in different individuals. Despite the strikingly high prevalence, autism remains one of the lowest-funded areas of medical research. The National Alliance for Autism Research (NAAR) is an organization that funds research that seeks to determine the causes, prevention and treatments of autism.

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Special cause: Walk for Autism Research on September 25 - "If you don't know someone with autism now, you probably will." This is the message being spread by the National Alliance for Autism Research (NAAR), as it tries to help people understand the urgency of its mission - to raise money for autism research with the goal of finding treatments and, ultimately, a cure for this complex brain disorder that often inhibits a person's ability to communicate, respond to surroundings, or form relationships with others. Autism spectrum disorders affect people of all racial, ethnic and socioeconomic backgrounds and occur in an estimated one in every 250 births. Recent prevalence studies suggest that more than 1,000,000 Americans are living with an autism spectrum disorder, making them the second most common developmental disability after mental retardation.

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The Help Group Summit 2005 - This conference features leading researchers, educators and clinicians in Autism Spectrum Disorders, Asperger's Disorder, Learning Disabilities and ADHD. Once a year the organization brings together some of the country’s leading experts to create a cutting edge conference addressing the most current facts and latest breakthroughs in research and treatment in autism, learning disabilities and ADHD. The Help Group Summit 2005 will take place on Friday, September 30, 2005 and Saturday, October 1, 2005. The location is - Skirball Cultural Center, 2701 N. Sepulveda Boulevard, Los Angeles, California CA 90049.

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John L. Waters talks about His Independent Research on Integration - To begin this article, allow me to say that my writings take an unusual approach, and some of my ideas might seem far-fetched. Because of the unusual nature of my life and work, I've taken over twenty years to study both rational and non-rational cognitive styles and in addition I've been consulting with professional experts in psychology and in other subjects, and several of these persons have written letters recommending my work. By John L. Waters

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Scientists begin to trace autism's genetic roots - Most 11-year-olds don't react to their first trip to the zoo the way Alex Richie did. "I shouldn't have come. I shouldn't have come." The Ferguson, Mo., boy's family hears that whenever Alex goes someplace new. A visit to IHOP would have been all right. Alex had been there. But even Disney World was traumatic. They don't serve Dr. Pepper there. "Alex wants out of his room and he wants to enjoy life," said his mother, Jessica Cooper, 32. But he is imprisoned in a world constricted by autism. By Tina Hesman

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Snapin: A protein with therapy potential for autism - A new paper by Firestein and her colleagues at Rutgers, The State University of New Jersey, examines the role of the protein snapin in nerve branch, or dendrite, patterning and its potential as a drug target in therapies aimed at learning and memory disorders. The article will appear in the journal Molecular Biology of the Cell but appeared online today at MBC in Press  www.molbiolcell.org/in_press.shtml While disorders like autism may arise from a multiplicity of causes, research at the cellular level, such as that of Firestein and her Rutgers team, is creating an important point of entry for early intervention with therapeutic drugs. / Release

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Men 'grasping at straws' over intelligence claims - Claims that men are more intelligent than women were met with scorn today - as girls once again trounced boys in this year's GCSE results. A paper due to be published in the British Journal of Psychology claims to have established a five-point difference in IQ scores between men and women.  There are more men with very high IQs and this explains why more men than women win Nobel prizes or become chess grandmasters, argue Richard Lynn, of Ulster University, and Paul Irwing, of Manchester University. "This is a last desperate stand by men to show they are superior. They see they are sinking and are grasping at straws," said Sue Povey, of University College London.  By Donald MacLeod

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Gender hormones may lend to social disorder therapies - Gender politics aside, every biologist knows that men and women truly are different. Social disorders such as autism constitute one area where those differences come to the fore: around 80 percent of all autism cases, for example, occur in men. Social play behaviors also differ greatly between the sexes - just about everyone agrees that young boys play "rougher" than girls.

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Genes for mathematical genius?- A British research team from the Autism Research Centre at the University of Cambridge has recently embarked upon the first-ever rigorous search for a maths gene. The scientists intend to search the DNA of 200 pairs of siblings for clues as to what makes a good mathematician. Mathematical ability is commonly thought of as an innate gift that some people are born with. Moreover, this gift, which often runs in the family, is coupled in many cases with other peculiar characteristics such as musical ability, spatial awareness and a lack of social skills. People with autism are not only challenged in terms of social skills, but can also show extremely high mathematical ability. The question remains as to whether this connection is due to genetics or due to nurture rather than nature. Mathematically minded families are more likely to foster the attraction of their children to this field by playing maths puzzles and games. Also, being a solitary business, maths is more likely to attract introverted individuals when they are still young.

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NIH scientists can no longer consult for drug companies - After accusations that some government scientists used their official positions for private gain, the National Institutes of Health announced rules on Thursday that ban scientists from consulting for drug companies.  "Our research should be based on scientific evidence that is not influenced by any other factors," Dr. Elias A. Zerhouni, director of the health institutes, said at a news conference. The rules were issued after disclosures that scientists at the institutes had leveraged their positions to land lucrative consulting contracts that seemed to conflict or at least overlap with their official duties. Those contracts caused some critics to worry that research by the agency could be tainted. An investigation by the agency concluded that 44 of its 1,200 senior scientists appeared to have violated rules governing consulting and that nine might have violated criminal laws.  By wire services

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Research Project - The University of Texas at Austin - Project Title: Understanding the decision making process that parents use in selecting treatments for their children with Autism or Down Syndrome IRB# 2002-10-0098  ...Read more.

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STUDY links brain's genetic 'off switches' to autism - Providing one more clue for solving the autism mystery, researchers have discovered that the brain mechanism that stops or slows nerve impulses contributes to the disorder. A team at Duke University Medical Center in Durham, N.C., found that genes that serve as "off switches" in the brain's neurons play a role. Exactly how such genes interact and what happens in the brains of autistic children remains unknown. But the findings are sure to intrigue the many parents of autistic children who have long suspected their children suffer from a sensory overload. The study will be published in the September issue of the American Journal of Human Genetics.

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Cluster Of Genes Suspected In Autism - Researchers have uncovered important genetic clues to the cause of one of the most baffling brain disorders - autism. Scientists at Duke have found some of the first hard evidence that suggests that a group effort by genes in the brain's information filter may play a key role. It's estimated that as many as 10 to 100 genes may be involved in autism. Now scientists at Duke have uncovered some of the first evidence that those genes don't act alone.

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Le Bonheur Neuroscience Team Expands Excellence with Opening of ... - The opening of a dedicated neurology clinic and the arrival of three pediatric neurologists at Le Bonheur Children's Medical Center are a result of the commitment the hospital has made to its Neuroscience Institute. World-renown neurologist Dr. James W. Wheless began these expansion efforts when he arrived at Le Bonheur in May 2005 as the new Neuroscience Director. "Our goal is to raise this program to a Level IV national epilepsy program for children," said Wheless. "We want to get to the point where any epilepsy treatment that is available anywhere in the world would be available for children here also." / Release

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Family key to gene study - An Australian family has played a key role in the breakthrough discovery of a gene associated with intellectual disability that may also have implications for people with severe epilepsy and autism. Studies of the Boltwood family, of Bella Vista, in Sydneys northwest, were crucial in the identification of a gene which researchers believe will provide insights into how the brain works.

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New Hyperbaric Treatment Center - Children whose lives have been changed by the simplicity of oxygen gathered for the grand opening. Patients and their families cut the ribbon this morning outside the hyperbaric oxygen center in downtown Madison. Hyperbaric oxygen chambers treat neurological conditions by literally pumping oxygen into the brain.

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Study Hopes to Find Cause of Autism - Autism is a devastating brain disorder with no cure. On the healthbeat, Dr. Kim Mulvihill looks at efforts to track down the cause of the mysterious disorder. Nancy Andrieu of San Francisco has two sons. Both boys are diagnosed with autism. Nancy Andrieu, Mother of Two Autistic Sons: "We're struggling along, trying to get them services, helping them overcome their disabilities, and trying to find out why this happened."  To date, no one knows what causes the baffling brain disorder, but Nancy -- and most experts --suspect the answer lies deep within our DNA. Nancy Andrieu: "It's definitely genetic."  By Dr. Kim Mulvihill

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Autism study will monitor families' need for timeout - A new research project is aiming to help families cope with the demands of autism. Mt Albert resident Gillian Wright is a research consultant for the project and has two children with intellectual disabilities, including a 16-year-old son with autism. The project will study families with 16-25 year old family members who are affected by autism and explore the need for "respite" services. Ms Wright describes respite as being positive time that the young person has away from home and family in a different environment. Respite usually involves participating in structured activities or programmes with other young people who have similar needs. "Kids with autism have problems with social interaction. Respite can be a chance to do different things and be with different people," she says. Respite can also provide a break for other family members from the pressures of caring for an autistic young person. By Nicole Stanley

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Consider HCT 1026 for very young autistic infants and toddlers ... - Consider HCT 1026 (a nitric-oxide donating derivative of flurbiprofen) for treatment of very young autistic infants and toddlers, in combination with intensive educational intervention (the latter of which has shown scientifically to help autistic children function better).  I base this recommendation on the work of Lennart Gustafsson Ph.D. who has suggested that inadequate expression of Nitric Oxide in critical points of brain development are predicted to lead to narrow cortical minicolumns (shown to occur in autistics on autopsy data per the work of Manny Casanova M.D.). How safe is HCT 1026 in young children? What are the potential side effects? A researcher who might be interested in this is Mirjana Maletic-Savatic M.D., Ph.D. She is a pediatric neurologist and researcher interested in autism, and has studied neuronal Nitric Oxide Synthase knock-out mice relative to this. She is at the University at Stonybrook in New York in Pediatric Neurology. By Linda Copeland M.D.

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Multiple Genetic 'Flavors' May Explain Autism - While debate still rages over the 'cause' of autism, mounting evidence suggests that genetic factors play a major role in the disease. Two recent studies led by James Sutcliffe, Ph.D., and Randy Blakely, Ph.D., investigators with the Vanderbilt Center for Molecular Neuroscience and the Vanderbilt Kennedy Center for Research on Human Development, suggest that multiple rare mutations within a single gene may increase risk for autism. Their findings also may point to new therapeutic options for this devastating disorder. Source: Vanderbilt University Medical Center

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Scientists Scour DNA For Clues To Autism - Nancy Adrieu of San Francisco has two sons, both diagnosed with autism. "We're struggling along, trying to get them services, helping them overcome their disabilities and trying to find out why this happened," she says. However, to date, no one knows what causes the baffling brain disorder. But Nancy and most experts suspect the answer lies deep within our DNA. Now, a high tech tool invented in the Bay Area may reveal some real answers. The technology is called a "gene chip DNA array." The chip allows scientists to examine the DNA found in a blood sample on a much finer level and more rapidly than ever before. Thanks to the chip, and 1500 families hit hard by autism, a massive hunt looking for genetic clues is now underway. "In order to find these genes, we need large sample sizes," says Dr. Joachim Hallmeyer of the Stanford School of Medicine, who is part of the international effort involved with the research. "The goal of all this is to treat autism better."  By Kim Mulvihill, M.D.

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Multiple rare mutations within a single gene may increase risk for Autism - While debate still rages over the 'cause' of autism, mounting evidence suggests that genetic factors play a major role in the disease. Two recent studies led by James Sutcliffe, Ph.D., and Randy Blakely, Ph.D., investigators with the Vanderbilt Center for Molecular Neuroscience and the Vanderbilt Kennedy Center for Research on Human Development, suggest that multiple rare mutations within a single gene may increase risk for autism. Their findings also may point to new therapeutic options for this devastating disorder. In this pair of studies, the researchers identify and characterize a number of mutations in the gene that regulate brain levels of serotonin, a neurotransmitter involved in many biological processes including breathing, digestion, sleep, appetite, blood vessel constriction, mood and impulsivity.

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'Gene test' for autism in sight - Scientists who have discovered a gene linked to autism believe they can use the new knowledge to work out an individual's risk of the condition. The French team from IntegraGen SA hope to have a working risk assessment test on the market by the end of 2006. The gene sits on chromosome 16 and holds the DNA code for a protein that plays a central role in brain function.  Experts said the Molecular Psychiatry study was promising but that it was premature to talk about an autism test.

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Hormone Won't Treat Autism - Despite its initial promise, the intestinal hormone secretin does not improve autism symptoms and should not be used to treat the disorder, say Australian researchers who reviewed 14 studies involving 618 people with autism.  Scientists led by Dr. Katrina Williams, of the Children's Hospital at Westmeade, concluded that intravenous doses of secretin -- considered by some to be a promising treatment for autism -- did not improve autism-related social, behavioral or communication problems.

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Larry Young on animals and autism clues, environmental impact on ... - Young began studying voles for their monogamous behavior, then investigated molecular mechanisms in species behavior differences. Now researchers are gaining insights into human disorders with social impairments like autism. Keynoting an APS conference on oxytocin/vasopressin Young points to studies confirming their roles in social cognition and suggesting a developmental role for oxytocin in shaping normal adult social behavior. / The full press releases are available on the APS Press Room conference website: the-aps.org/press/conference/index.htm  The American Physiological Society  http://www.the-aps.org

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Multiple genetic 'flavors' may explain autism / Two recent studies suggest that multiple rare mutations within a single gene may increase risk for autism, according to investigators with the Vanderbilt Center for Molecular Neuroscience and the Vanderbilt Kennedy Center for Research on Human Development - While debate still rages over the 'cause' of autism, mounting evidence suggests that genetic factors play a major role in the disease. Two recent studies led by James Sutcliffe, Ph.D., and Randy Blakely, Ph.D., investigators with the Vanderbilt Center for Molecular Neuroscience and the Vanderbilt Kennedy Center for Research on Human Development, suggest that multiple rare mutations within a single gene may increase risk for autism. Their findings also may point to new therapeutic options for this devastating disorder. In this pair of studies, the researchers identify and characterize a number of mutations in the gene that regulate brain levels of serotonin, a neurotransmitter involved in many biological processes including breathing, digestion, sleep, appetite, blood vessel constriction, mood and impulsivity.

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New STUDY SHOWS COMPELLING EVIDENCE OF major intestinal immune disease in children with autism / Thoughtful House scientists and collaborators confirm link between autism and new inflammatory bowel disease - In a study that provides further clues to understanding the origins of autism, scientists and physicians from Thoughtful House Center for Children in Austin, Texas, supply considerable evidence of a new inflammatory bowel disease in children with autism. The study will be published this month in the European Journal of Gastroenterology and Hepatology.

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Study Confirms High, But Stable, Child Autism Rate - Concerns over an "epidemic of autism" may ease thanks to research by MUHC investigators. The study, published in the American Journal of Psychiatry this month, reveals that although pervasive development disorders such as autism are more common than previously believed they are not increasing. "Our initial study, conducted between 1992 and 1995, revealed that 0.63% of children surveyed suffered a pervasive development disorder," says Dr. Eric Fombonne, one of the study's authors and Director of the Department of Psychiatry at the Montreal Children's Hospital and Head of the Division of Child Psychiatry at McGill University. "This result was triple the autism rate of 30 years ago." The new study aimed to replicate this research, using subsequent cohorts of children under the same experimental conditions, to establish whether autism is on the rise. By: MUNC

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Hormone won't treat autism - Despite its initial promise, the intestinal hormone secretin does not improve autism symptoms and should not be used to treat the disorder, say Australian researchers who reviewed 14 studies involving 618 people with autism.  Visit our Autism Centre for more information.

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Exercising the brain- How do you brace yourself when you discover your child has not met the developmental milestones? For instance, your two-year-old toddler has yet to learn how to walk. At three, your child has yet to utter a word and appears to have poor eye contact. At six, your child is inattentive and is unable to grip a pencil.   Attention deficit disorder, autism, cerebral palsy, mental retardation and pervasive developmental disorder are just some of the terms used to define persons with developmental delays. But it is not always so clear cut that a child has a specific disorder. Which is why some experts are reluctant to label a child because to them, it is just a way to describe the symptoms of an injured brain. By

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Secretin should not be used to treat autism, researchers say - The intestinal hormone secretin, considered by some to be a promising drug in the treatment of autism, does not improve the symptoms and should not be used to treat the disorder, according to a new review of studies.   After analyzing data from 14 high-quality studies involving 618 patients with autism disorders, Dr. Katrina Williams of the Children's Hospital at Westmeade, Australia, and colleagues found no evidence that doses of intravenous secretin improve the social, behavioral or communication problems associated with autism. Secretin "should not currently be recommended or administered as a treatment for autism," the reviewers conclude. There were no serious side effects reported in any of the studies, but "more adverse events are likely to be reported if secretin is made widely available," Williams says.  By Betina Andersen

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Specialists from Brazil and abroad attend symposium on human brain - of the Federal University of Pernambuco (UFPE), in Recife, Northeastern Brazil, for an international symposium on the human brain. The event, which begins today, runs until Friday (22).  According to the coordinator of the event, João Ricardo Mendes, the purpose of the symposium is to discuss advances in the treatment of diseases that affect the brain, such as autism, depression, memory lapses, and Alzheimer's disease, as well as psychiatric disturbances with clinical, behavioral symptoms. He recalled that, to keep the brain healthy, one must constantly develop intellectual activities, such as the habit of reading.  By Márcia Wonghon

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Research Information Request:  AS in the Miltary Service  - The author will be working with Department of Defense decision-makers and others to develop personnel policies uniform throughout all of the US armed forces affecting reporting, evaluation, and administrative protocols for retention, reassignment, and separation from the service.

The author requests those who have been in the active, reserves, or National Guard military service to please contact him so that he can complete a second article on AS and the military.  That article will focus on identifying, evaluating, reassigning or separating AS individuals from the service with an emphasis, in all such steps, on a "soft landing."

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Latino Families of Adolescents and Adults with Autism: A Study of Family Caregiving - Family caregiving of persons with autism is an important, emerging area of study. Within this area of research, there is virtually no research on Latinos with autism and their families. Working with Marsha Seltzer, Jan Greenberg and Marty Krauss, I am supervising recruitment of a sample in Massachusetts of Latino families of adolescents and adults with autism. Some of the issues we will explore are the relationships of family and acculturation to caregiver well-being, parental beliefs about autism, and service utilization among this population.

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Clues to autism’s mysteries - There comes a point in every great mystery when a confusing set of clues begins to narrow. For scientists who study autism, that moment may be near, thanks to a combination of new tools for examining brain anatomy and of old-fashioned keen observation. Within the last year, several laboratories have reported finding important new clues about the mysterious syndrome that derails normal childhood brain development. For the first time, they say, a coherent picture is emerging.  By Sandra Blakeslee

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Studies focus on detecting autism early / Believing swift diagnosis aids treatment, experts are refining new techniques to spot a serious brain ailment. - In an exam room at the Kennedy Krieger Institute, 2-year-old Lexi Koller makes her way slowly up a set of toy wooden stairs, holding her arms out for balance. At the top, she stops and breaks into a wide smile. "Yea! Good girl! You climbed up the mountain!" says therapist Alison Nelson. Over the next two hours, Lexi chases soap bubbles, builds towers out of blocks, looks at books, plays with baby dolls and kicks a soccer ball. The goal of all this activity: To spot the first signs of autism, the mysterious brain ailment that afflicts more than a million Americans. By David Kohn

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Rats Infected as Newborns Grew Up Vulnerable to Memory Problems - Underscoring the value of good prenatal care, new research suggests that early infection may create a cognitive vulnerability that appears later during stress on the immune system. Researchers at the University of Colorado at Boulder have reported that rats who experienced a one-time infection as newborns didn’t learn as well as adult rats who were not infected as pups, after their immunity was challenged. The research is in February’s Behavioral Neuroscience, published by the American Psychological Association (APA).  The findings fit into a growing body of evidence that even a one-time infection can potentially permanently change physiological systems, a phenomenon called “perinatal programming.” Source: American Psychological Association (APA) 

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UCSD institute awards grants to 12 - Studies about memory, hypnosis and learning by infants are among 12 projects that have won grants from UCSD's new Kavli Institute for Brain and Mind, the university announced yesterday.  The institute aims to elucidate connections between the biology of the brain and the workings of the mind, including memory and consciousness. Fred Kavli, a Santa Barbara physicist and industrialist, created the institute in November with a $7.5 million endowment. By Bruce Liberman

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Marijuana Use Affects Blood Flow in Brain Even After Abstinence - People who smoked marijuana had changes in the blood flow in their brains even after a month of not smoking, according to a study published in the February 8 issue of Neurology, the scientific journal of the American Academy of Neurology.

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New Study Finding Increased Autism in Kids Whose Mothers Have Psoriasis /  Underscores Dramatic Need for More Psoriasis Research - A new study in the February issue of the Archives of Pediatrics and Adolescent Medicine found a troubling association between a mother's psoriasis and her children's autism. The study, which reviewed more than 88,000 children born between 1995 and 1999, found that only one immune disorder present in the mother, psoriasis, was "significantly associated" with an autism spectrum disorder. "Psoriasis Cure Now!," a psoriasis patient advocacy group, responded to the troubling new findings. By Michael Paranzino of Psoriasis Cure Now!

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OHSU scientists, others study ailments of autistic children / The Autism Treatment Network seeks standards of care and will look at sleep and stomach disorders. - Oregon Health & Science University scientists hope to start searching this fall for health problems common in autistic children, part of a national effort led by a Lake Oswego group. The Autism Treatment Network unites six health centers, including OHSU and the University of Washington, whose scientists will test ideas about autism-related diseases. The nonprofit models itself after the Cystic Fibrosis Foundation and related groups, whose research has led to new national standards for medical care.

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